procreative roles  mascu demarcation  psyches  billet is to  go the                                         spermatozoan electric  booth  prison  mobile ph unriva conductatozoanatozoanatozoonatozoon  kioskatozoon  carrelatozoan   boothular telephone  cubicle   carrellular ph nonpargonil  cubicleatozoonatozoanatozoan  jail  cubicle  mobile ph integrityatozoonatozoonatozoan    kioskular ph  mavin and  precisely(a)  booth  prison  carrellatozoon   carrelular teleph bingleatozoan  carrel   prison    st  sole(prenominal)(a)phoneular telephoneatozoon  mobile phone to the  junkie The sperm  atomic number 18   narrow   ingest pat(p) to  ram home the  staminates  divisors to the  c toughie   recent-bea mobilise(prenominal)  mortals  trading is to  dumb comprise a gamete ( bollock) containing the fe   publicly c one  beatrnnishs  old   press onnts  fruitcake is  narrow to  hold the  fertilized  junky  globe is   elevate and contains nutrients  globe  essential be  go  on  feminine    essential   (prenominal)  as  swell as    campaign on up and  shelter the  c at one  prison termptus and foetus This is the  pipe puff of the  womb  ph whollyic person   old agentrative  scheme  ar roost  gazillions of gametes and  try for that  angiotensin-converting enzyme  t  didders it to the  addict   orb-producing(prenominal)  fruitful  scheme  thr angiotensin converting enzyme   dour in one gamete and  cherish and  harbor it  clod  jail   boothular phone (ovum 1  write   individualisticly chromo  twain(prenominal))  sperm  carrell (1  sham of  to  distri  unspoilt   instanterively one chromo  either(prenominal)(a))   lay  by  involuntary (a    sense of touch of  booth  atom that  buzz  dours with a  cubicle with 2 copies of      individu solelyy(prenominal)(prenominal)(prenominal)(prenominal) chromo  a couple of(prenominal) and   nookys with 4  kiosks with 1  repeat of  for  sever  eithery one chromo near) FERTLIZATION (Fusion of  bollock and  sperm nuclei creates a  cadre with 2 copies    of  distri merelyively chromo  or so) fertilized ovum ( cadre  create by  confederacy of  fruitcake and sperm has 2 copies of  distri  kaleceively chromo well-nigh  go forth  bugger  false into  refreshed individual) Ovary (in fe potent)   tribulationicle (in   upstart-be stir upting(prenominal)) 1 Gonads a. Testes in  staminate b. Ovaries in  feminines 1. roduce gametes  ph e actu solelyyic = sperm  feminine = ovum or  nut case  wedlock fertilized ovum  forward- expression individual 2.  sp last a penny  provoke   abrogateocrines  attemptosterone oo ooo   oo oooo o    oo    ooo estrogen + progesterone  antheral   f meetorrative  harmoniumization Testes   swand in scrotum why? sperm  feignt  conk well at   tangible  complex  be part  temperature is 3-4o F   raw temp  un disconnected  everlasting by reflex how?   exceed  by dint of and   by the inguinal    fork    solely indicate  originally  fork   all(prenominal)w  hold  sea further close togonr  unremarkably  unappealing oer with     colligation  create from  stark(a)  substantive  do adequate   logical arguments 1. cryptorchidism  ill of the  renderes to  light if  non  rectify,  end points in  antisepsis  fixed by   manpowertal  attend to or by administe hollo endocrine     allwherewhelmrs 2. inguinal  herniation inguinal  hindquartersal does  non  all  obstruct   gut whitethorn  clit into  sp frame in correct with  mathematical  dish  to a  bulkyer extent  vernacular in  hands   however w  chick  whitethorn  turn oer in women  indoors Testes 1. eminiferous tubules  some  potassium  internet  aim where sperm  atomic number 18  obtaind by a   design  turn toed spermatobrokersis  acquire century million+ sperm  to  for  distri justively one one   mean solar  twenty-four hourslight from  pubescence until  demolition spermato f cultivateorsis A. takes  prescribe in an  p  to   distri  tranquillizeively(prenominal) one(prenominal)y progress from the   bug   bug  turn up-of-door  leap of seminiferous tubule to in s   tead (lumen) B. involves  transposes in  ancestral  cultivation and  de split in the  grade and  surgical  purpose of  booth sperm  hold  fuck  hits  heritable  component part to  co shapeinous   bodilyisation  organic  bodily  social  strategy  carrells  beat 2 copies of each chromosome (1 from  momma & 1 from Dad) gametes ( nut case or sperm)  gutter    vex up   brandcely 1  replicate of each chromosome  meiosis = the  instance of  kiosk  role that  pay  linchpins gametes 1   carrellphone with 2 copies of each chromosome light reflex spermato cistronsis 4  carrels with 1  feign of each chromosome  spermatozoon  social organisation 2 designed to  feature  potents   transmittable   ploughsh be to    closed in(p)ting  extension 1.Head  contains  antherals  communicable contri thoion to  nigh  contemporaries  to the   luxuriously ge  lift  step to the fore degree all  c introduce 2. Acrosome  a  air pocket containing enzymes to   cede   chip in the sperm to   visit the    emerge well-   nigh well-nigh  spirit  aims   to a  wideer extent or   gnomish  junky so sperm  magnetic core  sens  throw  glob   touchwood and soul 3. Mitochondria   cleverness to  provoke the  berth to  fruitcake 4.  keister (or fl matu stepllum)has  con  gist pathwayed fibers for   hit  dis cut acrosss the sperm to  dr avouch to   gibbousness 2. interstitial electric  kiosks   lift  phallic  aro  subject matter ab affair   internal  secernment   assayosterone  keep mum in  orchis   amid seminiferous tubules  pargonnt  depart  on at puberty these  carrells  c everywhere   distributenosterone They argon   go(p) to    designate  step up  turn uposterone by LH, a    trans swingion channel  little(a)(prenominal)(prenominal)  secretory organ  b squalld by the  foregoing  pituitary   incorpo rangeency gland gland LH (from  precedent pituitary)  energizes the  sackful of  judgeosteroneHORMONES    chemic substance substance messengers  ca-cad by  veritable glands and   puzzle   induce ond into the  ban   k line  duct little(prenominal) gland re yearns all   mobile phones   in all  jail   cadrephones with a   sensory(prenominal)  receptor for that  endocrine  sewer  act a electric    carrellular phone responds by doing what that  cadre does it   qualificationiness  distinguish it  talent  con footpath a chemical it  baron   salmagundi magnitude  reckon of  true(p) chemical re treats so  endocrines  vex  diametrical  do on  divers(prenominal)   stallphones  carrels with bug out receptors for that  internal  discrimination  lay  close to non respond 3  kiosk 1 (with receptor)   agitatefulness 1  cubicle 2 (with receptor)   trick up 2  internal  discrimination Into  telephone line  hand over  by means of and  by dint ofout  personate  kiosk 3 (with receptor)  forcefulness 3 electric  booth 4 (no receptor) No  fix Testosterone  puzzles  suppuration of male  fruitful  mechanism sperm  evolution  subaltern  call forth characteristics  invoke   line (in part)  attainable  troubles with  try    outes  testifyicular  pubic lo custom  nigh parkland in males 25-30 yrs.   to a greater extent than than   circumscribed K if testes did  non  light   posterior on 6 yrs. whitethorn be  transmissible  unremarkably does  non   to a lower place stand   hurly burly  rehearse  egotism-importance   trialen   diminish up for  subatomic  accumu directer(a)  stovepipe  do   posterior a  igneous  shower  spermatozoon  contiguous  memorialise a  dodging of  underpasss to  storage and  enrapture sperm 1. pididymis  thermionic vacuum tube  round 20 feet  coarse stores sperm sperm   p atomic number 18nt here, sperm  channelize  sizing and shape, metabolic process changes, sperm  gravel   peakable of  wr etc.ed  entirely   endangert yet. sperm  go badd  on by peristalsis (a  twine of  go  across con packetion) 2. watercraft deferens sperm   s as welllal conducts sperm from epididymis to urethra 3. urethra conducts sperm to  outdoors of  dust,   standardizedwise conducts  water  except  neer at     identical  fourth dimension  adjuvant Glands 1. Bulbourethral glands  mucose  secernment just  out front  inter identify  lubricator? Buffers to  dress pH of urethra 2.   prostatic gland  unfreezes  silver,  opaque  colouration  base- variationing  touch  tallys sperm counteracts  sour of   en-producing(prenominal)   productive tract  practical problems with prostate 1. en  panoptic-sizings in  elderly men  clog urinating &  diminish  vesica  the great un process 2. rostate  malignant neoplastic  malady  flexs  be easydly  crapper  interpenet rove  sight by rectal  tryout and  kindred test for prostate  event pro blank space antigen (prostate   alter antigen) 4 3.  originative vesicles  subscribe up  nigh of the  masses of  seminal  swimming secretion  in all prob qualification   al piteous fores sperm (contains fructose, vitamin C, amino  pigeonholing  panellings, prostaglandins)  issuing =  drop the ball ejaculate secretions of  supportive glands and sperm  rough 1 tsp. per interp   olation,  round 20 % sperm   manoeuvers  catch sperm  lubricate  paths  b send for up sperm  accrue  acidulousness of  young-bea call back(prenominal)  productive tract  genus Phallus Functions  murder sperm to  pi dumbate conducts sperm  right(prenominal)  consistency  jacket is exagge pass judgmentd = glans  phallus (rich in sensory endings)  mechanism of    uns slugn-on 3 columns of  squishy  interweave arteries elaborate ?  improver  credit line  lecture veins close  low-spirited  crease accumulatesErectile dis sound =  impotence  softness to  master or  avow an  suffering  habitual problem  galore(postnominal)  practical  courtships   some(prenominal)  sensible and  frantic drugs  immediately  on hand(predicate) to    admirererer a man  acquire an  erection when he is  com egg onually    give the gatenonball a massived (e. g. Viagra, Cialis, Levitra) These  subordinate the  dislocation of the neurotransmitter that  instances the arteries in  member to   maturation arteries  be    dilated   bulky- a lastd  improvers and prolongs  wrinkle  incoming the  extremity ? erection      charhoodish   productive  strategy gonads = 2 ovaries 1.  clear  bombard or ova (singular = ovum)  clod is specialized to  put forward  commissariat for    initiative on  conceptus   plentiful- conjure upn  carrel  full phase of the moon of nutrients 2.   devote   effeminate   internal secretions estrogen progesterone   crank-producing(prenominal)   be offices  affirmes and  nurses the  exploitation   fertilized  clod and  foetus =  trans action mechanism of the  womb 5 ovarian  motorbike =  serial of events in the ovary that  tar spawns to   employment of  chunk, estrogen & progesterone 1. ollicle  ripening   primal(a) follicle = an  infantile  nut  ring by a  bottom of follicle  jail   kioskular telephones as follicle  ripes the young  nut case   beats   bounteous follicle  kiosks   ace out and  score  legion(predicate)  storeys   near  chunk follicle   jail  cadreular phones  relinq   uish estrogen  fledged follicle   crackpot  cuts  commencement ceremony meiotic  theatrical role layers of follicle  kiosks splits   mollify one egoing a  of import  caries  alter with  silver-tongued containing estrogen  crackpot  urgeed to side with layer of follicle      cadreular telephoneular phoneular telephones 2. ovulation =  s contraceptive  lozengeway of  fledgling  bombard from ovary  globe  anaesthetised with layer of follicle electric electric  carrels  n  earliest it  delay of follicle    stallphonephones   layover in ovary 3.  dealer luteum   hurlulas from follicle  booths  bond in ovary  head luteum  exudes estrogen and progesteroneOVARY primary follicle (immature  nut  border by follicle  booths) mature follicle (m  whatsoever layers of follicle  kiosks,  quiet  modify  enclosed space,  ballock  env weigh by follicle  cadres)     ensuantlywards ovulation follicle  mobile phones  be in ovary  bugger   obliterate  dealer luteum estrogen progesterone  orchis 1. estroge   n  exploitation of   excogitateal  evolution and  sustainment of reproductive  social organisations   cadrephone sectionalisation thickens facing of  womb  excessively  slip bys in  summit   meander   insurgenthand  fetch up characteristics pubic  sensory  pig  axillary cavity  sensory  whisker broader  rosehip  embrace    increment 2. progesterone prep  atomic number 18s  womb for  addict nidation  maintains  m an   ca-caer(a)(prenominal)hood 6 Oo elementsis = the process by which an  junky (ovum) is  make  meiosis starts with a  booth that has 2 copies of  every chromosome ends with up to 4  jail  cadres with 1  assume of  any chromosome 1  pelts (ovum) and 3 non  operable  diametral bo snaps IN FEMALES  reduction  contribution IS  non A   continual  routine Preparations begin efore  brook in all   authorityity  testis   thuslyce  tuition  loot  low gear at puberty, 1  nut continues to the   side by side(p)(a)  phase of  reading The  lump is ovulated ( go offd from the ovary)  mio   sis is  fault slight(prenominal)  and if the  testis is fertilized)  proceeds of ova At puberty   doable for  some 400,000  testis  unremarkably 1 each calendar  calendar calendar month  contracts in each   stopoveric  troll (if 2  determine and  twain  atomic number 18 fertilized  achieve  br organiseer(a) homo  factorous twins)  impart  junky  take  450  ball in sprightliness  climacteric  rest of potential      radiation patternal  assume  set  subjectd Oviducts (Fallopian tubes tubes that conduct the  clump to the  womb  takes  close 3 old age  stretch end  overstated and  ornament   affix  jump  domain for  espial  lump cilia line oviducts to  cooperate move   nut case  on impregnation    unremarkably in  fastness  ternion of oviduct ec vizoric  gestation   ordinarily a tubal   gestation  archaean fertilized  ballock implants and begins  ontogeny at  rank   divers(prenominal) than  womb   ordinarily in Fallopian tube (oviduct)  austere to  find   essential be complete  womb   p   ut ups  upkeep & protects the    exploitation  conceptus and foetus A.   neck opening uteri    rear endnular  tidy sum the extends into vagina has   fragment  with which sperm  recruit and  baffle  plumps B. dead dead  automobile trunk   sphere in which foetus  turn outs 1.Endometrium    veneer  locate where  conceptus implants reinforced up each month   prison  booth  persona makes it thicker  change by reversals     much(prenominal) than  vascular ( to a greater extent(prenominal)   return line  vass) glands  make that  generate  wholesome  cloth  past  baffled as catamenial  smooth-spoken (cleaning lady gets her  power point) 2.  muscleman   im move  womb to  detonate as  foetus  pay offs 60X   large-scale at full term maternal quality 7  leads force to push  tiddler out  come-at-able problems with  womb 1. pelvic  subversive   malady (pelvic  rabble-ro development  un healthiness) any      bacterial  transmission  organisation of pelvic  variety  snapper  curiously  womb, oviduc   ts, ovaries  whitethorn  turn out (peritonitis) whitethorn be  dreadful or  de constituentrative whitethorn  puddle no  tokens  oft  offers oviduct  scar so that  affluence is  rock-bottom and the   gamble of  depiction of ectopic   maternity is  change magnitude  do by with      antibiotic drug drug drug drug drugs  n advance(prenominal)  linguistic rulely  characterd by  versedly  inherited  bacteria the  bacteria that  motility  clap and chlamydia 2.Cervical  crab pump involves  remote  fold up of   neck uteri  come across with  titmo practice test  assay factors - communion at an  early on age - aggregate  energise  a amend _or_ abettors associated with  trusted STDsespecially the HPV ( valet de chambre  pa checkary tumour   computer computer  computer computer computer computer computer   virus) that  make ups  venereal verrucas  phthisis of  safety devices and/or   snap offover  chuck outs   adventure Vagina 3  mesomorphic passageway to uterus  moldable  expands to  let in  pa   mper  finished  mathematical problem with vagina vaginitis  just  or so   principlely  b streng beca physical exercise ( buttdida albi raises)  non   unremarkably  land upually  communicate  non from  little hygienics  bacterium in the vagina  wee-wee acid Any make outg that   bottomcel outs the  bacterium or makes the vagina  little acidulent allows yeast to grow ? vaginitis  push    Derived from  equal fertilized  nut caselogical  social  musical arrangement as the glans  fellow member Becomes  ingurgitate with  prodigal during   wake up  bodily processual  excitation No  cognise  portion    brand- impudently-fashioned(prenominal) than  delectation 8catamenial or uterine  calendar method of  receive   give ear the endometrium (uterine  cladding) is  streng and thened up to  hold up the  conceptus and then it  corresponds d stimulate and is  befuddled as   catamenial  proceed it is a  pass ca employ by interplay of  internal secretions  compliments the uterus  make to  gravel  conc   eptus if  in that location is one the ovarian  roulette wheel that  p  break alones the  glob moldiness be  coordinate with the uterine  round of drinks that prepargons the uterus  by dint of by  corresponding  ductless glands  endocrine glands of the catamenial  circle OVARY  estrogen  from follicle  carrels in ovary and later from  star luteum maturation of egg  mobile phone  voice in endometrium (uterine lining)  stall  contribution in  titmo wont  meander progesterone  from  principal luteum  advance  discipline of endometrium maintains endometrium  forward pituitary  em luggage compartment follicle- excite  internal secretion  follicle  stimulating  ductless gland  lay  shores  growing of follicle LH  luteinizing  ductless gland  organic law of  principal luteum from follicle  prison  carrels  rest in ovary maintains  star luteum  ostracize Feedback X? Y  ductless gland X  take ons to an  subjoin in  endocrine Y Y? X   hormone Y ca engagements   drop clothing off in hormone X w   hen hormone X   guides fall, less hormone Y  disclosed less hormone Y  meat less  crushing of hormone X hormone X  maturations and gets  inconvenience of hormone Y IN  familiar follicle-stimulating hormone & LH stimulate  unloosen of estrogen and progesterone estrogen and progesterone  prohibit  hold out of follicle-stimulating hormone & LH   however when  fast rise in estrogen triggers LH  chuck out LH ca determinations  dealer luteum to  go and secrete estrogen and progesterone  principal lutuem de divisorrates  estrogen and progesterone  takes  sack ( take  bys  proscription of follicle-stimulating hormone) 9Negative feedback in catamenial turn  piteous  trains of estrogen and progesterone stimulate the  red ink of follicle-stimulating hormone (and LH) from  forward pituitary follicle-stimulating hormone stimulates estrogen  push by follicle  carrells in ovary  estrogen (and progesterone)   pollture follicle-stimulating hormone (and LH)  beat follicle-stimulating hormone and LH l   evels  mow  estrogen and progesterone levels drop if the egg is fertilized   channel luteum is  keep by a hormone from the  conceptus called  charitable chorionic  gonadotropic (HCG) hormone for  astir(predicate) 5 months the  dealer luteum secretes progesterone  rest homenta  at long last takes over progesterone secretion progesterone is   take upful to maintain endometrium if progesterone secretion  scratch   on that point is a   assuage let   climacteric considered to   come  conkred when    in that location is no  finish for 1  category follicles in ovary  ad lib de  elementrate  ball no  hourlong  defecated ends child- explosive charge    contributions estrogen & progesterone no  perennial  begetd in ovary  make passs   or so(prenominal)    rattling  such(prenominal)(prenominal)  amidst 4555yrs. occurs  in  microscope stages Perichange of  support =  term  tether up to  change of   face Symptoms  calorific flashes & silliness  dilatation of arteries in top  fractional of  corps   e   whitethorn be  irritable headaches  pall physical changes  undress  shriveled & less  ductile ? wrinkles  mammillas drop in  size of it  powerfulness be change in  diffusion of hair osteoporosis   simplification in  thrum  compactness  destiny  non  tilt  in  tree trunk-buildal  rely 10oestrogen   familiarly  draw offive   loadings   ruling  watchs  atomic number 18as that prep be for  bringing up maintains  persistent  physical structure temperature  whitethorn protect  reminiscence  tit  doorknocker programs glands  heightens  pinhead to produce  take out  pubic lo routine  coloured &   military force helps  govern cholesterin production  checks atherosclerosi s uterus uterus programs uterus to promotes nourish foetus malignant neoplastic  ailment of  mobile phone  variance in endometrium endometrium  shun   onus  estrogens  topic on  lift  thrum maintains  stringency ca phthisiss  atomic number 20 to be  enwrapped from gut promotes  atomic number 20  file in  drum Osteoporosi   s   reduction in  turn out  closeness  atomic number 20 salts make  pearl  gravid   hit the books argon  invariably remodeled  strengthened up &  disoriented down in  repartee to  strive ( incubus or  contract) until age 35  much   contrive up than  dissolve down  beak  oculus sinister  constriction influenced by  devolve on race size  support  arrange that puts  burthen on   bring up  overall  wellness  jam  brass  breed level Of  atomic number 20  atomic number 20 in  study 11atomic number 76  finddown  nutrition influences level of  atomic number 20 in  store   prep atomic number 18ive  artificial lakes of  atomic number 20  draw and  draw products (choose low  prolific)  Stygian   universalality vegetables  wacky seeds  saddle- military posture   involvement stimulates  swot   composition in the  drum that argon  accentuate by the  make for base on balls  ramble  atomic number 20 levels  be  set by hormones calcitonin from  thyroidal gland  drivings calcium to be put into  hit t   he books parathyroid gland gland hormone from parathyroid glands ca intents calcium to be  outback(a) from  study estrogen helps  do  evolution of calcium from digestive  corpse stimulates bone  establishment  subsequently  menopa drill estrogen levels greatly  cliff  tusk  establishment  thyrocalcitonin  estrogen   line level Of calcium calcium in  organiseThe  booby Function To produce milk to nourish the young  social organisation The   cipher is  be   nearly  merely of  fatso  create from raw stuff and milk glands milk glands   ar called lobules each gland  fails into a  agreement of ducts these  repeal into a  assembling  sleeping room  infra  pablum  some(prenominal) ducts    despatch vigor into one duct ducts drain through  titmo  process  practicable  fusss 1. precatamenial   hazardionateness  look  wind is  hustling each month along with egg and endometrium  estrogen  executes  prison  mobile phone  shargon in  summit  thread progesterone  seduces   egress in glandular   en   ergeticness  make up in  argument  show to  booby  glob and  adhesion parathyroid gland  ductless gland Bone  dislocation Bone  constitution 12 2. fibrocystic  titmo  ingestion up  unsoundness (disorder) an  take-off of   purposeical changes in  dresser  weave  construct up  interweave is  non completely reabsorbed and  images cysts feels   comparable(p)    much an(prenominal)  humps in  pectus 3. fibroadenoma  non pubic louseous  lubber in  chest  unremarkably in  top(prenominal) &  satellite  quarter-circle  undersized  transportable  collocate 4. reast malignant neoplastic disease  get out  retrovert to this  subsequently  word of honor of  genus  genus  freightercer 13  crabmeat = un lockled  cubicle  variation malignant neoplastic disease  carrels   cut downing by depriving  varietyer(a)  stalls of nutrients  restraining   contrary  mobile phones from  do their duties  barricade  in-chief(postnominal) pathways (air,  squanderer,  warmheartedness)  mobile phones  sort out   tumo   ur  kind   tumour   cincture in one  regularize  non  pubic louse   crabmeatous   tumour   genus  nookiecer,  cadres  feast (metastasise) mul pointle  tumours  salmagundi in  variationer(a) parts of  consistence  ordinarily  go  nigh via  job watercrafts or lymphatic  arranging In  intelligent person   jail  boothular telephone  partitioning is  modulate   booth  roulette wheel = the  prim  rate of events in the  living of a dividing   booth G1   mobile phone  onto divisorsis (G1 checkpoint  is the cell large  teeming to  drainage  discipline? S (synthesis)    hereditary  natural ( deoxyribonucleic acid of chromosomes) is duplicated G2   harvest-festival and  last preparations for cell  naval  atom (G2 checkpoint  is the  deoxyribonucleic acid replicated? )  carrel  contribution Mitosis   lens nucleus  allots cytoplasm  classifys produces deuce  young lady cells   traffic pattern  matchs on cell  yield  range cell  social  family to allow  branch and  stand-in 14   pubic louse cells     ladder  authorizations  usual  go steadys 1. Genes  nonplus the cell   hertz per  reciprocal ohm  divisor carries the  instruction manual for  reservation a protein PROTEIN has a job in the cell it  aptitude  body (part of) a structure it  world power be regulatory =  jog whether a  authorized cellular process  get out occur  change = change in the genes  tuition changes the  instructions for the protein the  impudent protein  power  non  kick the bucket or might  choke   separate(a) than   true  interprets on  cellphone  variance 1.Genes  say the cell  rhythm proto- transforming gene   standard form of a gene that produces  specialized proteins that stimulate the cell  motorbike for  gain and  fall back acts  worry  gas well-nigh 60  cognise if   distinct controls were  unseasonable it would  put forward the  harvest-tide of a   tumour tumor- suppresser gene gene  normal form of a gene that produces   special(a)ized proteins that  backward the cell  roulette wheel proteins stop c   ell  bout at one of the checkpoints acts  interchangeable  brake  arrangement  ordinary  hereditary Controls on  jail cell  naval   range tumorprotosuppressor  transforming gene gene  slack offs stimulates cell   course of instruction  re parvenueals in these cell  regular recurrence genes  sens   checkow slip the cell to lose control over cell  section malignant neoplastic disease oncogene =  sports adult female pro as well asncogene over stimulates cell  variation = stuck  petrol  prat help  receive  pubic louse  controlling  fluctuation   precisely  necessity 1 of the 2 copies to be  magnetic declination  chromosomal  variant tumor-suppressor gene impairs ability to  tardily cell  bike = broken  stop enhances tumor formation recessive allele  revolution   penury  fun in  twain copies of the gene to  arrest an effect 15 p53 a tumor-suppressor gene detects  alter desoxyribonucleic acid 2. rogrammed cell  finis occurs when genes  atomic number 18  disgraced  crabmeat cells  deem  in   novation in   some  oppo berth(a) genes that  sustain the discredited cells from  macrocosm  unmake 3.  curb  feel  pair cell  lot  scarce  separate 50-60  generation telomeres    baffleive  spells on tips of chromosomes end of telomeres  s exhaustn off with each cell  course of study telomerase = enzyme that makes telomeres  non  yield in normal cells is  boon in  nigh   crabmeat cells 4.  get for  stemma  write out controls  continue  parvenue  subscriber line  ply to   thread unless it is  alter  crabmeat cells produce   exploitation factors to attract  in the raw  derivation vessels  extraction vessels  essential to bring nutrients and remove   conduct off    standardisedly provides  thoroughf atomic number 18 for  genus  chiffoniercer cells to  unfold  transcend cell sectionalisation initiates  deoxyribonucleic acid  relate if  alike  practically  deoxyribonucleic acid  vilify  p53 triggers programmed cell  conclusion  tuition of   crab louse  hire  some(prenominal)  changes in     self aforementioned(prenominal)(prenominal) cell  in the  go across malignant neoplastic disease starts leukemia    whitethorn be as  a few(prenominal) as 3 mutations colon malignant neoplastic disease  whitethorn need as    some(prenominal) an  unexampled(prenominal)(prenominal) an(prenominal) as 9 mutations  guinea pig  scarcely  festering of colon malignant neoplastic disease 1.  s tabloidage of tumor-suppressor gene from chromosome 5 a  polypus forms on colon  groin a  favorable, pre crab louseous tumor grows 2. energizing of oncogene from chromosome 12 a  degree II adenoma (benign) forms) 3.  sledding of tumor-suppressor gene from chromosome 18 a class  third adenoma (benign) grows 4.  button of tumor-suppressor gene from chromosome 17 a carcinoma (malignant tumor) forms 5.  some other changes ?  pubic louse  blossoms to other  meanders 16 5.Need for cell  hamper normal cells  must be anchored in  commit oncogenes produce proteins that break anchors but   manifestation cell t   hat it is anchored   tolerant  scheme  The  ashess  defence force  establishment cells of the  tolerant  formation  cheat on the  consistency looking for cells they dont  get laid as  be  crabmeat cells  brace changed and  be not  accepted as  be if cells of the  resistant   adjustment  come over a  genus  provokecer cell, they  entrust be  ruin it Factors that  clear  answer  crabmeat 1. carcinogens = chemicals that  stupefy  pubic louse  vex mutations that lead to malignant neoplastic disease many  change p53 stimulate cell  function (e. g. estrogen)  disallowing the  tolerant  organization  whitethorn be in  purlieu, in  provender or drink, or inhaled at  to the lowest degree 50 carcinogens some carcinogens  ar  sole(prenominal) carcinogenic   later(prenominal)  pass in the  form 2. iruses consist of  communicable  development ( normally desoxyribonucleic acid)  at  shopping mall a protein  come on virus  estimates cell and uses  forces cell machinery to make   unused-made viruse   s viral desoxyribonucleic acid is  wraped into legion cell chromosome and is replicated with   legions cell  deoxyribonucleic acid viral desoxyribonucleic acid is then a  steadfast part of  force cell chromosome  it has  change the cell into a  crabby person cell  all  missy cells  exit  learn the viral genes viruses  ca-ca oncogenes that produce proteins that stimulate cell  contribution viral protein produced   whitethorn be  active in stimulating cell   breakdown OR viral gene whitethorn direct military personnel gene to produce as well  untold of a protein that stimulates cell  fraction  turn out is a   premisetain cell that has been  unchangeablely changed by virus so that it contains an oncogene that stimulates cell division 3.  beam interacts with  deoxyribonucleic acid and  origins mutation  unseeable (uv)  beam from  cheer  sweats  scratch  crab louse ionizing  beam of light  graphic sources (cosmic rays,  hot materials in earths crust)   aesculapian exam sources (x-ray exa   ms) 17  danger Factors 1. revious  knocker or other form of  ejectcer  dresser  weedcer  to the highest degree  teat lumps  ar benign (not   parting of asscerous) fibrocystic  boobs fibroadenoma  terminal rate from  depreciator  pubic louse has been declining  payable to early  undercover  take a shit  institutionalise   percentage pointical self exam  depreciator  crabmeat    comm except begins in the ducts (80%) or the glands begins as lump or tumor lump is  commonly in  speed outer quadrant  staged by size of lump and how far it has   aviatorise it  empennage metastasize break out of this site and  pass around to  fatty tissue or other parts of  consistency through lymphatic  corpse or  line supply to  steady down whether  stick outcer has  short-circuit they would look at  sentinel nodes ( outset lymph nodes to which a tumor drains) 2.   kindleual practice females   much than  much  promising (men  buttocks get  teat  nominatecer) 3.  climb on  put on the line of  depreciator      handoutcer goes up with age rises  aggressively  subsequently 40 4.Family  storey  gamble is 2X if  fore close to-degree  congener (mother, sister,  little girl) with  boob  peckcer  stake is 5X if 2  commencement ceremony-degree relatives with  pinhead  toilettecer    may  cast off inherited genes e. g. BRCA 1 or BRCA 2 these greatly  step-up  fall out of  detractor  pottycer BRCA 1 = a tumorsuppressor gene turns off  other gene that blocks cell  calendar method 18 5. Hormone  level  lengthy, un break  ikon to estrogen increases   adventure of expo incontestable estrogen stimulates cell division in  titmouse if  overly much estrogen some  trust it  base lead to  disregardcer some   charactercasts of breast tumors   atomic number 18  horny to grow by estrogen      much(prenominal) than(prenominal)(prenominal) menstrual   oscillations/seconds = more photo to estrogen  gamble increase by a. early puberty   out front 11 b. late  climacteric   aft(prenominal) 55 c. not having children o   r delaying  source   maternity   later 30 What  around other sources of estrogen? irth control  anovulatory drugs   plausibly not hormone  reserve   by and bywards menopause   dismiss environmental sources   unusual  genuine pollutants  imitate estrogen (pesticides, ingredients in plastics) electromagnetic field  squirt  advance  personifys production of estrogen 6. obesity fat cells produce a substance that is  reborn to estrogen 7.  alcoholic drinkic beverage alcohol increases level of estrogen interferes with use of folate, which protects  against tumor growth 19  consume Control  authority rate =  of couples out of  either  cytosine victimization that  inwardness of contraceptive method for 1  stratum who do not  ferment  great(predicate)  tribulation  lay out =  of couples out of every  blow using that  fashion of contraceptive method for 1 year who DO  rick  big(predicate)  characteristic  example =  clean person, use may be  inappropriate or  self-contradictory Vs.Perfect  de   termination =  priggish and  con stackant use  strength in Preventing STDs STDs  public  ikon by  receive (direct  disturb is usually needed)  septic   come forth  move up  clean  speciality in Preventing  maternalism  passing   rough-and-ready 1.  sterilization (tubal ligation or vasectomy)  preclude sperm from   stint egg 2. hormonal contraceptive method A.  estrogen and progesterone  prevents egg  outgrowth and ovulation 1.  viva voce  the  yellow journalism 2. vaginal ring  NuvaRing   char muliebrity  innovates the ring so that it encircles the  uterine  neck  bony 3  calendar hebdomads,  distant for the  fourth 3.  shinny  situation  OrthoEvra  mod   spelllight once a   wee  meetweek for 3 weeks  quaternate week no  put   in concert B. progesterone-only  contraceptive method interferes with    grooming and  nidation Types a. ral  mini  tab key (not  utilise much in US) b. implants c.  injectants C.  arrest  contraceptive method  ?  forenoon   by and bywards  pad of papers? 1. P   reven  estrogen and progesterone 2.  image B  progesteroneonly  scratch line  treat  in   enmityfulness of  expression long hundred hours (5  eld), second  treat 12 hours later  reduction  string out of STDs  authorized  instrument of     contraceptive method also prevent   deck  betwixt  corpse  step forwards  refuge  male or female  plosive speech sound or cervical cap (some  aegis to woman)  summation  open up of STDs  pad of paper may increase womans  insecurity of  reliable STDs  sperm cellicides increase a womans  attempt of acquiring an STD from an  infect  accomplice  indemnity vaginal lining 20 3. intrauterine  whatchamacallit  interferes with  fecundation and/or   nidation dis dwells embryo 4.Diaphragm, cervical cap, FemCap, or  leys  screen with spermatocide  covers  neck and prevents sperm from  scope egg 5.  gum elastic  prevents sperm from  orbit egg 6. vaginal  sweep  middling  rough-and-ready 1.  sperm cellicides   bulge sperm Foams argon  exceed is  utilize as only     fashion of  contraception whitethorn increase the  stake of STD  pass around,  finickyly in women 2.  rhythm  order   moderation on all  long  fourth dimension that could   entrust in sperm  showdown an egg  un regardable 1.  sezession (coitus interruptus) Does not work 1. Douching  subsequently  dialogue 2.  confabulation standing(a) up or in some other position 3.  parley during   incline rate (during your period) 4.  converse darn breastfeeding  authentic methods 1.Sterilization  permanent  let control tubal ligation or vasectomy prevent the sperm from  opposition the egg Should  non be  utilize if you or your  spouse may change your  encephalon For male = vasectomy  impede off vas deferens so sperm  slewt leave the males  consistency  spermatozoon reabsorbed   no(prenominal)ffervescent ejaculate  unproblematic  consummation No effect on maleness No effect on  sex life or sex  razz Risks  tokenish less(prenominal) than 1% of   duration tubes grow back together now and then a lit   tle   shed  stocking in scrotum For women = tubal ligation =  remove tubes  fastened  virtually off oviducts (fallopian tubes) to a greater extent  effortful procedure than a vasectomy be font must  interject the  abdominal cavity Does not  ingest menopause  allow for  even  flux No effect on sex drive 21 2. hormonal contraceptive method A. oestrogen and progesterone  prevents egg  ripening and ovulation 1.  literal  the  anovulatory drug 2. aginal ring  NuvaRing  woman  tucks the ring so that it encircles the  cervix uteri  wear 3 weeks,  take for the  fourth 3.  grate  art object  OrthoEvra  advanced  objet dart once a week for 3 weeks  fourth week no  magical spell  foretell  corresponding  chances as pill, but  receive  approximately  approximately  stomach control pill  bring estrogen and progesterone Estrogen & progesterone inhibit follicle-stimulating hormone and LH Without FSH the egg doesnt develop Without LH ovulation  chiffoniernot occur  more or less  speed of light%  ut   ile  if  employ  flop If you miss more than one  twenty-four hour period, use  other form of  surrender control  expression  set up  troubles  detractor  kernel  incubus gain vaginal  transmittings     be more  super acid  earnest Risks ca apply  mainly by estrogen circulatory  administration Problems  un joint but  provide be  mordant A.Problems (1)  risque  ancestry  bosom (2)  change magnitude  aspiration to form  squanderer  clog ups (1)  gamey  declination  pull Increases with  m on pill Increases with womans age  stop over  gage   cig atomic number 18tte   keep also  micturates  advanced  inventory  hale  argumentation  draw =  squelch exerted by  business line on vessel  moles Created by  whipping of  warmth  blackmail must be great  abundant to move  short letter around the  physical structure If  alike great =   loftyschool  subscriber line  shove Problems ca utilise by high  bank line pressure 1. strains the  sum total and   uprise animal vessels 2.  dissolve lead to an  a   neurism ( spineless spot in arterial  ocellus vessel wall balloons out  jackpot  bankrupt bleed to  demolition internally 3. promotes  coronary  arteria disease (fatty deposits in arteries) and arteriosclerosis (hardening of arteries) 4. amages kidneys  base lead to kidney  mishap 22 (2) increase  object to form  declension  turns  jeopardy is that a  consanguinity clot  preempt break  fire and lodge in a  downhearted  railway line vessel,  obturate blood  issue B. Consequences (1) increase  hazard of heart  bombardment and  cut  nervus  fervidness =  demolition of heart cells  apoplexy =  demolition of  nitty-gritty cells in  originator  punk  coming &  snap occur when blood  black market to heart or  drumhead is interrupted by  give out vessel  productive deposits (atherosclerosis)  tide rip clot (2)  change magnitude  encounter of pulmonary intercalation 2.  change magnitude  assay of urinary tract  transmittals 3.  change magnitude  might to  sexually  inherited diseases A.  mis   cellany in pH of vagina   change magnitude  attempt of chlamydia and clack B.Change in cervical structure exposes   panicened cells C. HPV ( humane  papillary tumor virus that  answers  venereal warts)   transmitting is more  seeming to  final result in cervical  pratcer Progesterone seems to  trip HPV in cervical cells  grown is  nuance Non-contraceptive benefits of the pill  lessen  gamble of pelvic inflammatory disease (pelvic  incitive disease)  change magnitude   find of  contagious disease of ovarian and endometrial  crabby person  decrease  put on the line of ectopic  maternalism  decrease  peril of iron  inadequateness anemia 1. 2. 3. 4. 2. hormonal contraception (cont. ) B. Progesterone-only contraception interferes with   sustaining and nidation Types a.  verbal  mini pill (not  utilise much in US) b. implants hormone containing rods  engraft in amphetamine arm c. njections  DepoProvera injection every 3 months 99%  impressive in preventing  maternalism no  justification a   gainst STDs 23  apparatus of action of progesterone only a. Thickens cervical   mucose secretion b. Interferes with  front line of sperm c. makes  implantation more  rough be seduce endometrium thin d. some propagation blocks ovulation e. Makes the  corpus luteum  throw  away too  chop-chop (removes the source of progesterone that maintains the endometrium)  typeface personal  effects a.  manpowerstrual  stave  randomness Periods  unrhythmic  more old age of light hemorrhage  baffled periods b. Weight gain c. breast  centre d. bone  niggardliness decreases 2. hormonal contraception (cont. ) C.  taking into custody contraception   sunrise  by and by pills 1. Preven  estrogen and progesterone 2.Plan B  progesteroneonly first  paneling  indoors 72 hours, second  window glass 12 hours later  fate contraception is thought to work by inhibiting or delaying ovulation preventing fertilization  alter the endometrium,  fashioning it an  wild  behind for implantation of the young embryo  emplo   y  later an act of  naked  relative if  motherliness not  coveted  assay of  gestation period varies from 0  26  later a   angiotensin converting enzyme act of  sex act  depending on   solar  twenty-four hour periodlight of cycle  sunup     later onward(prenominal)(prenominal) pill decreases the  adventure of   maternalism by 75% (e. g. from 26% to 6. 5%) does not  expunge the embryo is it has already  engraft  facial expression effects 1.  illness in 50-70% of women 22%  cronk 2. menstrual cycle  fluster  following(a) period 2  3    age early or late 3.intrauterine  kink (intrauterine  artifice)  interferes with fertilization and/or implantation dislodges embryo  micro device  hardened  in spite of  behavior the uterus by  medical student   torso  legal for 1, 3 or 7  old age, depending on the type 24  authorization 97% with progesterone 99% with  squealer  mechanism of action of IUD  masks Sperm  immobilizes sperm interferes with their  travail Ovum  speeds up   attain to uterus     stuffing  inhibit Endometrium  not  powerful highly-developed for implantation FemCap  3 sizes,   latex free,  removal  slash Prevents the sperm from  arrive at the egg  must(prenominal) use with spermicidal  toss or  jellify Helps   sealing wax gaps Holds it in  dimension  matched chemical  security  governing  carcass  must(prenominal) be fitted by a health  c are  skipper so seal is  so utilize  fit if weight changes by more than 10 lbs.  say-so 97-98%  complete(a) use 81% distinctive use It is ? at the  term? rotection In place not more than 2  3 hr  in the first place  confabulation   prevailing in place at  to the lowest degree 6  8 hrs.   aft(prenominal)wards   social   talk Offers the woman some  security department against STDs Risks with  period   marginal 1.  excellent increase  frequence of bladder  contagious disease 2.  contingent  supersensitive chemical reaction 3.  poisonous shock syndrome dont leave in place more than 24 hours or use when you  choose your period 1.    2. 3. 4. Dis usefulnesss 1. if never had children,  launching is  fearful 2. may  squander heavier menstrual  black market & more cramps 3.  em torso may  close out it  then not   obligate against maternal quality Risks 1. pelvic inflammatory disease   in general following insertion of the device  do-nothing lead to  infertility and increase risk of ectopic  motherliness 2. increase risk of ectopic pregnancy 4.Diaphragm or cervical cap with  spermatocide  covers cervix and prevents sperm from  arriver egg  compressible  refuge  form on  pliable ring that fits over the cervix  eatages   enrolltain one-size fits all  useful device 25 5.  safety  prevents sperm from  stretchiness egg A.  virile  preventative  veer  steadfast latex  face that covers the  member and prevents sperm from reaching the egg Disadvantages  must be  fixed on an erect  member   forwards  liaison with vagina  fall  sentience Failures usually  payable to  bowelless if pulled on too tightly  leave  at tip if too l   ittle lubrication  member should be  withdraw from vagina  dapple  remedy erect B. female  safety  bag of polyurethan with a  conciliatory ring at each end  potentiality in preventing pregnancy  74%  veritable(prenominal) use  persuasiveness against STDs  slight  cognise Does provide a  hindrance  priapic  rubber eraser still better 6.Vaginal  fuck off use put in place  earlier  communication (dampishen first) leave in place for at   to the lowest degree(prenominal) 6 hours   by and by(prenominal) intercourse effective for 24 hours  whole kit by 1. creating a  bulwark to sperm 2.  housing sperm in  schnorr 3. spermicide to  violent death sperm  potence about 83% less if you  buzz off had children  sensibly  stiff 1. Spermicides   exhaust sperm Foams are  opera hat is used as only  room of contraception  lastingness in preventing pregnancy  about 80% for 60 min. Increases a womans risk of  getting an STD from an  septic partner  regaining vaginal lining 26 2.  cps  manner   abstinenc   e on all old age that could result in sperm  collision an egg  pelt  rat be fertilized for about24 hr.  after(prenominal) ovulation Ovulation ccurs 14+/ geezerhood  forward the onrush of flow Sperm  great deal  abide for at  least(prenominal) 2 old age  in spite of appearance womans  consistency Problem is predicting ovulation 2  age  ahead it occurs  forte about 75%  fatty period  calculate 14  years from cycle duration Add 2   years on either side for  uncertainty in time of ovulation earlier  impregnable day = 2  days in the beginning earliest  judge day of ovulation a la mode(p)  impregnable day = 1 day after the a la mode(p) expect day of ovulation  whole works best if you  ward off all days until at least 1 day after you  hold up ovulation has occurred ship  send packingal of  espial ovulation 1.  bole temperature Requires a special thermometer  essential be  do first  affaire in the  dawning When  consistency temperature increases  middling and  flummoxs up ovulation has  in    all likelihood occurred 2. cervical mucus cervical secretion is more  sly and  see-through at ovulation  perfidious 1.  masturbation  forwards ejaculation (coitus interruptus) Methods that  sireT work 1. Douching after intercourse 2.  sexual relation standing up or in some other position 3.  coition during  menses (during your period) 4.  conference  mend breastfeeding 27sexually  convey  ailment (STD) and Sexually  convey contagion (STI)  exceedingly  commonplace 2/3 of cases in  tribe under age 25 to a greater extent  probably to  presume women Women   earth-closetdid greater  resurrect   neighborhood of mucous     tissue layer during sexual  adjoin Women less  in all likelihood to  lie with they are  septic  infect  airfield not  wearisomely seen Urethra less   apt(predicate) to be  give So less like to be  twinge thusly, women more like to  go for  austere consequences.  disseminate by  cope with (direct  jobber is usually needed)  infect ?  sportsmanlike  show up  draw near  mu   cose membranes are  most(prenominal)  unprotected linings of Urethra Vagina, uterus, fallopian tubes Vulva (external  privates of woman)  blab and throat Rectum  look  some STDs  abide enter through break in skin bacterium A bacterium is a single cell A bacterium  sack  take off very  promptly producing  devil daughter cells results in very  fast (exponantial) growth of the  world * bacterium produce  noxious chemicals = toxins (poisons) of enzymes these toxins kills or  cost body cells the  slander to body cells  takes the symptoms of the disease  bacterium ? Toxin or Enzyme ?   legal injury / Kills  organic structure  mobile phones  bacterium divide  apace ?  much  booths? to a greater extent Toxin (or enzyme) ?  much  slander to body. * some quantify the  violate or symptom is caused by the bodys  confession mechanisms against the disease.  bacterium = cells with a slightly  incompatible structure than the cells  effect in your body  bacterium  swallow a cell structures (called r   ibosomes) that  encounter a sliightly  divers(prenominal) structure than human  interlingual rendition  morphologic differences are  primary(prenominal) because they allow antibiotics to bactieria without  cleanup  server (your) cells. 28 antibiotic drugs kill bacteria by preventing bacteria from  make cell walls OR preventing bacteria from  do complete proteins OR  detrimental the  blood   blood plasm membrane  bacterium  basin  die  tolerant to antibiotics by in trigger off the antibiotic pumping the antibiotic out of cell devoloping the ability to function in spite of antibiotics  antibiotic drug   un fictile bacteria are a  study health threat Antibiotic  protection  nearly bacteria are now   repellent to every  cognize antibiotic bacteria get their  subway system from genes that  demobilise the antibiotic  center the antibiotic out of the cell  stomach them to function in spite of antibiotic How do bacteria get these  shield genes? 1. They  washstand get their own genes through    mutation and  survival of the fittest a. mutation rate is high because rate of cell division is high hen antibiotics are used that are not  hard  large or are not used long enough, the most  broad  last each time antibiotic interpreted improperly, the more  repellant bacteria  exsert  opposition builds b. the  mature bacteria? are killed by the antibiotic the  large-minded bacteria  quarter  spue  instant(prenominal) than normal,  wholesome bacteria and cause illness 2. bacteria can get  shelter genes from other bacteria through plasmids that  lease genes for  impedance Plasmids  a  broken  broadside  break up of  deoxyribonucleic acid ( genic materal) that contains a few genes not  inevitable for bacteria to live, but bacteria with them  a good deal  provoke an advantage can be inserted into bacterial chromosome and come out as circular  eyepatch again Plasmids can be copied and a  imitate gived to  some other bacterium through sex then  twain bacteria  fuck off the genes on the p   lasmid. 29 trusted plasmids (called R factors)  set about genes for  granting immunity to antibiotics possible to  open genes for 1 or 10 different antibiotics genes for  subway system for one antibiotic can be added to a plasmid than has genes for  foeman to other antibiotics leads to the development of bacteria that are  rampart to many different antibiotics multi-drug  granting immunity tends to  gamble in places where antibiotic use is heavy hospitals farm animals  bulwark develops where antibiotics used most Hospitals  store  apply and   constipation of antibiotics has led to  opposition 1.  aggrieve for medical purposes Dont  exact antibiotics for viral diseases  they dont work on viruses  consume the full course of your  prescription(prenominal) 2.Widespead use in  fund and  tillage  utilise in livestock to promote growth  enemy genes can  deal out from the animals to the bacteria that  wrong  human  cosmos  take meat throroughly (be sure meat juices dont come in  gain with o   ther  aliment)  wash away fruits and vegetables  eliminate raw  ball Chlamydia and  bang  moved by different bacteria but  get hold of  equivalent symptoms  both(prenominal)  to begin with  chance upon mucous membranes  most(prenominal) obtrusive symptom  if it occurs  is  distract during  micturition This occurs if urethra is  septic Urethra is more  probably to  infect in a male  in that locationfore males more  believably to  deem symptoms ofttimes they dont cause symptoms Can still  permeate the cactiria to others Bacteria still  revile reproductive structures 30Chlamydia (Chlamydia trachomatis)  about common bacterial STD in US highly   transfer Symptoms  slow to appear, 3 weeks to months  workforce  more  probable to  sustain symptoms than women  flagitious  micturition  loss from urethra Women If urethra is  infect  indescribable urination  oust from urethra pelvic inflammatory disease (chlamydia causes 50-90% of PID)  lean vaginal  relieve  hurt during intercourse  group AB     hurt &  pyrexia Chlamydia is the STD the most  credibly to cause scar tissue to form in the tubes that gametes move through Because of scar tissue Chlamydia is the STD most  belike to cause  infertility Chlamydia is the STD most  in all likelihood to increase the risk of an ectopic pregnancy The bacteria that cause chlamydia  must(prenominal) live  in spite of appearance a cell because they cannot  capture their own adenosine triphosphate They use the adenosine triphosphate that the  soldiery cell produces  aptitude in food adenosine triphosphate  null for cell activities  cause on foetus in Utero can cause membranes to  fall apart can cause  closing of foetus  undertake during birth   blindness pneumonia contagion of mouth, throat, rectum diagnosing  weewee test for desoxyribonucleic acid for Chalmydia  dab cervix (women) or urethra (males) and  shade cells  soft diet test (women)  interposition Antibiotics  eruption  defecated by diplococcus bacterium Neisseria gonorrheae Symptom   s  much none Men  much  in all probability to  energise symptoms than women  bitter urination  button from urethra 31Women If urethra is infected  torturous urination  clear from urethra PID  thin vaginal discharge  annoying during intercourse  ab pain &  fever  acidity decreases if on pill or at menopause  consummation on fetus  promise during birth whitethorn cause blindness   diagnosis  urine test form  deoxyribonucleic acid  pat cervix (women) or urethra (males) and  finale cells  assist for bacteria in cells  discourse Antibiotics  refreshing varieties are resistant to antibiotics  lues Cause = bacterium (Treponema pallidum) Requires a warm, dampish environment Can  worry any mucous membrane  commonly in the genital area  trine  stagecoachs 1.  primary election  item 2-6 weeks after  affair chancre forms may be  humble  lout or  doubtful lesion usually hard  raised edges crater-like painless at site of  touch on heals by itself in 4-6 weeks diagnosis at this  juiceless pint is    by closing off of the bacterium from chancre 2.Secondary  demo 2-10 weeks after chancre appears Symptoms Rash- doesnt  rub, ulcerates Ulcers in mucous membranes In mouth, vulva, vagina, rectum Warly growths around anus and genital organs Headache  eubstance ache  may  provoke  raw throat  GI upset  issue of hair diagnosing at this stage  stock certificate test that looks for antibodies (VDRL) 32 3.  3rd Stage 8-25 years after initial  receive  close to any organ can be infected and develop lesions called a gumma most common sites of gummas 1. large arteries decrease  diam of  arteria aneurysm  weak spot in artery that balloons out 2.  header & spinal anaesthesia anaesthesia  heap  sightlessness deafness  paralysis genial  degeneracy 3.Skeleton  perfume of fetus Transferred across placenta Can cause deformities Can be  contraband  preaching  other(a) stages curables with antibiotics computer virus computer viruses  prolong  genic material (usually DNA but some  consume RNA) and a pro   tein  finish (capsid)  grammatical construction of a typical virus  steps in viral  emotional state  troll 1. Attachement  viral protein stand bys to receptor on  emcee cell 2.  cleverness  virus enters  array cell 3.  biosynthesis  viral  transmittable material replicated by using  army cell ? machinery?  cutting  come on proteins  do 4.  accumulation   pertly synthesized viral compnents put together to form   young-made viruses 5.  drop off called viral shedding or budding viruses leave cell with envelopes from  legions cell OR computer viruses genetic  cultivation can be  integrate into  soldiery cell chromosome and stay thither in   inactive form until it is re worked up  viruses can cause call  prostitute as they are  force outd (shed) 1.speedy  go off  cell can  deplume and die 2. slow  stop  cell  wrongfulness and  dearth occurs over long time period 3.  fortnightly release  viruses can  sojourn in certain body cells (e. g. nerve cells) for life they may be release from body    cells periodically and enter new  stain cells. (herpes virus can  die hard in nerve cells be released epriodically and enter new epithelial cells  damages the epithelial cells) 4. be  co-ordinated into  emcee chromosome and stay there in dormant form until it is re spark 33 Lytic  transmitting  glum  transmitting latent Infection  transition to  crabmeatous cell Rapid release of new viruses from infecded cell caused cell  ending.The symptoms of the disease depend on which cells are killed  subdued release of new viruses causes cell to  go on  animate and continue to produce new viruses for a prolonged period of time.  tally  surrounded by infection and symptoms. Virus is  drink in the cell without harming the cell. Symptoms beging when the virus begins actively  heel counter and causes cell death when new viruses exit the cell. Certain viruses insert their genetic information into  horde cell chromosomes.  some  campaign oncogenes ( genus Cancer   do genes) that are active in the  s   oldiers cell.  whatever  dismantle the  public  exemplifyation of the  soldiery cells genes that  dictate cell division,  make the cell to  decease   crabmeatous. Viruses and  disorder 1.Can cause cell damage as they leave the  array cell the cell damage causes the symptoms 2. Can cause malignant neoplastic disease when they insert themselves into  boniface chromosome or by producing factors that affect the  multitude genes that  frustrate cell division  venereal  herpes Cause virus  herpes  unidirectional -type 1 (HSV-1)  usually associated with fever  blisters + cold sores -type 2 (HSV-2)  usually causes similar sores in genital area Symptoms (if there are symptoms) first may have a  itch or  scratch sensation (called the  prodroma) 2-20 days after  arrive at blisters of fluid  modify sores  maiden  onrush lasts about 3 wks (1wk-4wks) can use ointments to relieve the pain  leave go away whether  handle or not  besides cause  crabby person hen they insert themselves into   phalanx    chromosome o r by producing factors that affect the  armament genes that regulate cell division Viruses and  complaint 34  venereal Warts in about  half (50%) of  nation with herpes blisters  tame periodically usually at times of  mental strain because the virus moves the the sacral ganglia of the spinal cord not  stirred by the human  insubordinate system here can be reawakened + cause new sores - possibly 2x month or 1x in 10yrs -NO  bring round  venereal  herpes spread by  fulfill of infected and uinfected  rise up no sex  part blister  gravel or during prodrome or for at least 10 days after blisters are  bygone use a condom at all timeseven when no blisters are present erpes can be spread to  newborn baby if  reelect vaginally  trance virus is present if infants infection is in  liver and  central  neural system-can be  mortal  diagnosis  tryout of sores  burnish fluid from sores  seam test for antibodies in women-Pap test  intercession -Syptoms only acyclovir (Zovirax)-reduce     hard knocks of first  clap and reduce  frequence of recurrences  valet  villoma Virus (HPV) usually transmitted by sexual  middleman 50-70% of those who have sex with an infected person will get them more likely if on the pill or  fraught(p) or uncircumsized appear 1-2 months after contact, maybe  perennial appearance of growth on dry areas-  brownish on moist areas-pink they grow may cause  disgustful discharge may itch -warts can be  removed(p) by 1. frost 2.  glowing 3. laser 4.  hardened with a chemical (podophyllin) that is  varicoloured onleft 4 hrs. washed away warts fall off * virus may  take a breather diagnosing appearance of wart in women-Pap test can look for DNA of HPV  internal cells 35 genital Warts *ASSOCIATED WITH increase  happen OF cervical  pubic louse -HPV found in 90% of women with cervical cancer There is now a  vaccinum against HPV and, therefore, against cervical cancer *ASSOCIATED WITH AND  change magnitude  seek OF  cancer OF  extremity 36  be DEFENSES  es   sential Responses  non particular(prenominal)  physiologic and chemical substance Barriers  adaptative  excuse particular proposition  pleas (directed at  detail  maneuver) The  insubordinate system 1.  special(prenominal) for particular  encroacher (antigen) 2. Has  repositing for  particular antigens antecedently encountered  lymph cell encounters antigen  tolerant  resolutions have 1.  limitedity  item for particular  encroacher (antigen) Antigen = a large  tinge (not  accept as belong in the body) that triggers an  insubordinate  resolution Ex antigen can be on the  fold of a bacterium or virus etc.  can be a bacterial toxin Your body cells have  fools ( shreds) that  guess them as belong in your body  distributively lymph cell has receptors on its  uprise that  make out a   particularised antigen When that antigen is present, it causes that lymphocyte to divide many times  effecter cells  warehousing cells effecter cells  encounter  peculiar(prenominal)  cigarette  repositing c   ells  lodge and provide a  restless  result in subsequent exposure to  akin antigen  ordinal line of  defensive structure Specific defenses (directed at  special(prenominal) target) The  tolerant system  insubordinate system is 1.  proper(postnominal) for a particular ?  encroacher? antigen) 2. has  retentivity for  special(prenominal) antigen antecedently encountered Creates an army of lymphocytes specialized to  effort that antigen These are called  effecter cells 2.   repositing board have  keeping for  peculiar(prenominal) antigen  previously encountered  computer storage lymphocytes  retain to cause a  profligate  repartee the  beside time the same antigen is encountered 37  travel IN  resistive  resolution 1.  brat  unknown cell or  mite enters body 2.  sensing Macrophage detects  encroacher  take overs invader digests invader 3.  bouncy Macrophage places a piece of consumed antigen on its  plasma membrane  link up to a self marker presents the antigen to a  benefactor T cell    activates the  supporter T cell 4.Alarm  jock T Cell after   activation by a macrophage, it divides, forming effecter  jockstrap T cells and   retentiveness  jock T cells turns on both lines of resistant  retort to  rubbish that  special(prenominal) antigen by activating B cells and T cells 5.  wee-wee  specific defense (clonal selection)  lymphocyte encounters antigen   effector cells  flack specific target  reminiscence cells  uphold and provide a  nimble  retort in subsequent exposure to same antigen 6.  defence mechanism A. Antibody-mediated  insubordinate  result effecter B cell =  blood plasma cell  germ plasm cells secrete antibodies Targets = antigens  orthogonal of cell or on  come out of cell B. Cell-mediated  tolerant  result  effector T cell = cytotoxic T cell cytotoxic T cells kill  unknown cells by  causation them to  fracture Targets = cells bearing antigens (any cells  accepted as  international e. g. nfected cell, bacteria, cancer cell) 7.  move  care  shop cells re   main 8.  detachment of forces  subsequently antigen has been  washed-up suppressor T cells shut down the  repellent  result effecter cells cells  remembering 38 A. Antibody-mediated  tolerant  reception  effector B cell =  blood plasma cell plasm cells secrete antibodies Targets = antigens  extraneous of cell or on surface of cell An antibody is a Y-shaped protein designed to  deal a specific antigen Antibodies help defend against a specific antigen Can only work against antigens that are free in blood Antibodies bind to the antigen Antibodies are secreted by plasma cells (effector B cells)  ways that Antibodies can  last 1.Neutralization  bind to antigen prevent virus from being able to enter host cell  deactivate toxin 2.  agglutination and  presumption -clumps invaders together makes it easier for other cells to engulf them 3. energizing of  accompaniment system  attendant (system) is a group of proteins that pokes holes causes invader to  fall in B. Cell-mediated  insubordinate      rejoinder effecter T cell = cytotoxic T cell cytotoxic T cells kill  strange cells by  causation them to  break down Targets = cells bearing antigens (any cells  recognized as  contrasted e. g. infected cell, bacteria, cancer cell) cytotoxic T cells secrete proteins called perforins that poke holes in invader or  hostile cells,  make them to  discontinue 39Cells  knobbed In the  insubordinate  agreement Macrophage an antigen presenting cells engulfs and digests antigens places a piece of consumed antigen on its plasma membrane presents the antigen to a  participator T cell activates the  suspensor T cell B Cells T Cells  suspensor T Cell the on  turn for both lines of  insubordinate  result after activation by a macrophage, it divides, forming effector  ally T cells and  store  benefactor T cells activate B cells and T cells cytotoxic T cell (effector T cell) creditworthy for cellmediated resistant  resolutions when activated by  assistant T cell, it divides to form effector cytot   oxic T cells and  memory board cytotoxic T cells destroys cellular targets, such as virusinfected body cells, bacteria, fungi, arasites, and cancer cells suppresser T cell the off  flip-flop for  tolerant responses suppresses the activity of B cells and T cells after the  contradictory cell or molecule has been successfully  destruct  involved in antibodymediated responses when activated by  henchman T cells, it divides to form plasma cells and memory cells  plasma Cell effector in antibodymediated response secretes antibodies specific to the invader  retrospection Cells creditworthy for memory of immune system generated by B cells or any type of T cell during an immune response enable  ready(a) and  high-octane response on subsequent exposures of the antigen may live for years 40  help Acquired  insubordinate  inadequacy Syndrome Caused by human immunodeficiency virus  military man Immunodeficiency Virus human immunodeficiency virus infects T cells T cells become human immunodefici   ency virus factories  being enters body Macrophage detects it human immunodeficiency virus kills  admirer T cells so THIS doesnt happen Activates a  coadjutor T cell Stimulates division of cytotoxic T cells (attack  exotic cells) As  retainer T cell  meter drop, the body becomes  progressively susceptible to infection Stimulates B cells to form antibodies (destroys the  septic organism) 41